Sematilide
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| MeSH | Sematilide |
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| Template:Longitem | C14H23N3O3S |
| Molar mass | 313.42 g/mol |
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Sematilide is an antiarrhythmic agent. It is the same structure as for procainamide, differing only by the placement of a mesyl sulfonamide moiety to the anilino nitrogen.
Synthesis
Sematilide can be synthesized from benzocaine (1).[1][2] Reaction with mesyl chloride, followed by saponification and removal of the water from the reaction mixture, gives sodium 4-[(methylsulfonyl)amino]benzoate (2). Chlorination with thionyl chloride gives 4-[(methylsulfonyl)amino]benzoyl chloride. Amide formation with N,N-diethylethylenediamine (3) then concludes the synthesis of sematilide (4).
References
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- ↑ Script error: No such module "Citation/CS1".
- ↑ David D. Davey, William C. Lumma, Jr., Ronald A. Wohl, U.S. patent 4544654 (1985 to Schering A.G.)
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