Selamectin
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Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats.[1] It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.Script error: No such module "Unsubst". It is structurally related to ivermectin and milbemycin.Script error: No such module "Unsubst". Selamectin is not approved for human use.Script error: No such module "Unsubst".
Veterinary uses
Selamectin is applied topically.[1] It is not miscible in water.[1]
Mode of action
Selamectin disables parasites by activating glutamate-gated chloride channels at muscle synapses.[2] Selamectin activates the chloride channel without desensitization, allowing chloride ions to enter the nerve cells and causing neuromuscular paralysis, impaired muscular contraction, and eventual death.[2]
The substance fights both internal and surface parasitic infection.Script error: No such module "Unsubst". Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands;Script error: No such module "Unsubst". parasites ingest the drug when they feed on the animal's blood or secretions.Script error: No such module "Unsubst".
Side effects
Selamectin has been found to be safe and effective in a 2003 review.[3]
Selamectin has high safety ratings, with less than 1% of pets displaying side effectsScript error: No such module "Unsubst".. In cases where side-effects do occur, they most often include passing irritation or hair loss at the application site. Symptoms beyond these (such as drooling, rapid breathing, lack of coordination, vomiting, or diarrhea) could be due to shock as a result of selamectin killing heartworms or other vulnerable parasites present at high levels in the bloodstreams of dogs.Script error: No such module "Unsubst". This would be a reaction due to undetected or underestimated infections prior to using the medication, rather than an actual allergic reaction to the drug itself.Script error: No such module "Unsubst".
Society and culture
Brand names
Script error: No such module "Unsubst". Selamectin is sold under various brand names including Selehold, manufactured by KRKA, Selarid manufactured by Norbrook Laboratories Limited, Revolution and Stronghold manufactured by Zoetis, Revolt manufactured by Aurora Pharmaceuticals, and Senergy manufactured by Virbac.
Similar products
Script error: No such module "Unsubst". Main rival products for dogs include ivermectin (trade names Stromectol, Ivermec and others) or milbemycin oxime (Interceptor) for heartworms, imidacloprid and moxidectin (Advocate), fipronil (Frontline) or lufenuron (Program) for fleas, or the combination milbemycin oxime/lufenuron (Sentinel) for both.Script error: No such module "Unsubst".
References
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