SPG11
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Template:Infobox gene Spatacsin is a protein that in humans is encoded by the SPG11 gene.[1][2][3]
Function
Spatacsin, in combination with the SPG15 protein, attaches the AP5 adaptor complex to the outside of late Endosomes or Lysosomes when the protein via which it binds is in a particular state.[4]
Pathology
Mutations of the SPG11 gene cause a rare form of spastic paraplegia, spastic paraplegia type 11.
References
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Further reading
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