SNW1

Template:Short description Template:Infobox gene SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.

Function

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

Interactions

SNW1 has been shown to interact with:

• CIR,
• Calcitriol receptor,
• Histone deacetylase 2,
• Mothers against decapentaplegic homolog 2,
• Mothers against decapentaplegic homolog 3,
• NOTCH1
• Nuclear receptor co-repressor 2,
• Nuclear receptor coactivator 1,
• PABPN1,
• RBPJ,
• Retinoblastoma protein, and
• SKI protein.