SMG1
Template:Short description Script error: No such module "For". Template:Infobox gene Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.[1][2][3][4] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
Function
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[4]
Interactions
SMG1 (gene) has been shown to interact with PRKCI[5] and UPF1.[6]
References
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Further reading
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