SLITRK6
Template:Short description Template:Infobox gene SLIT and NTRK-like protein 6 is a protein that in humans is encoded by the SLITRK6 gene.[1][2]
Function
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[1][2]
Clinical significance
Mutations in SLITRK6 cause high myopia and deafness in humans and mice.[3]
As a drug target
The protein is the target for the antibody-drug conjugate ASG-15ME which is in phase 1 clinical trials for urothelial cancer.[4]
References
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Further reading
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