SH2

SH2 may stand for:

• SH2 (classification), a Paralympic shooting classification
• SH2 domain (Src Homology 2), a protein domain within the Src oncoprotein
• SH-2 Seasprite, an American-built ship-based helicopter
• SH-2, an iteration of the SuperH CPU core developed by Hitachi
• Shadow Hearts: Covenant, also known as Shadow Hearts II
• Silent Hill 2, a 2001 survival horror video game, or its 2024 remake
• State Highway 2, see List of highways numbered 2
• Sh2, the second edition of the Sharpless catalog