SFRP2

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Template:Short description Template:Infobox gene Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.[1][2] This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[2]

New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury [1].

Cancer

SFRP2 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[3] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[3]

References

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Further reading

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