SETDB1

Template:Short description Template:Infobox gene Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as KMT1E or H3K9 methyltransferase ESET.

Function

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.

During meiosis, synapsis of homologous chromosomes ensures correct homologous chromosome segregation. Asynapsed homologs are transcriptionally inactivated by a process of meiotic silencing. Meiotic silencing depends on the DNA damage response network. SETDB1 protein has been identified as the bridge linking the DNA damage response to chromosome silencing in male mice.

Interactions

SETDB1 has been shown to interact with TRIM28.>

See also

• SETD1A, a protein that is highly homologous to SETDB1

External links

• Template:FactorBook
• Template:PDBe-KB2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.