SDZ SER-082
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SER-082, or SDZ SER-082, is a selective serotonin 5-HT2B and 5-HT2C receptor antagonist or weak partial agonist with an ergoline-like structure which is used in scientific research.[1][2][3] It shows similar affinity for the serotonin 5-HT2B and 5-HT2C receptors and has ~40-fold higher affinity for the serotonin 5-HT2C receptor over the closely related serotonin 5-HT2A receptor.[1][3]
Usages
It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[4][5][6] and how they influence the effects of other drugs such as cocaine.[7][8][9] The drug has been found to have no effect on anxiety in multiple paradigms in rodents.[10] In contrast to other serotonin 5-HT2C receptor antagonists, SER-082 does not produce hyperlocomotion in rodents, and instead can produce hypolocomotion at high doses that is independent of the serotonin 5-HT2C receptor.[11]
It fails to block the effects of serotonergic psychedelics in multiple behavioral paradigms, in contrast to serotonin 5-HT2A receptor antagonists.[12][13][14] However, the hypolocomotion induced by high doses of the phenethylamine psychedelic DOI can be attenuated by SER-082.[15] Conversely, the drug was ineffective against the hypolocomotion induced by the tryptamine psychedelic 5-MeO-DMT, whereas the serotonin 5-HT1A receptor antagonist WAY-100635 was effective.[16]
See also
References
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