SCH-58261
Template:Short description Template:Drugbox
SCH-58261 is a drug which acts as a potent and selective antagonist for the adenosine receptor A2A, with more than 50x selectivity for A2A over other adenosine receptors.[1] It has been used to investigate the mechanism of action of caffeine, which is a mixed A1 / A2A antagonist, and has shown that the A2A receptor is primarily responsible for the stimulant and ergogenic effects of caffeine,[2] but blockade of both A1 and A2A receptors is required to accurately replicate caffeine's effects in animals.[3][4][5][6] SCH-58261 has also shown antidepressant,[7] nootropic and neuroprotective effects in a variety of animal models,[8][9][10][11][12][13] and has been investigated as a possible treatment for Parkinson's disease.[14][15]
See also
- CGS-15943
- Istradefylline (KW-6002)
References
<templatestyles src="Reflist/styles.css" />
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".
- REDIRECT Template:Purine receptor modulators
Script error: No such module "Navbox".
Template:Cardiovascular-drug-stub Template:Nervous-system-drug-stub