SAP18
Template:Short description Template:Infobox gene Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.[1][2]
Function
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.[2] Additionally, SAP18s splice variants are implicated in apoptotic cycles.[3]
Interactions
SAP18 has been shown to interact with
References
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Further reading
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