Roflumilast
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Roflumilast, sold under the brand name Daxas among others, is a medication used for the treatment of chronic obstructive pulmonary disease,[1] plaque psoriasis,[2] seborrheic dermatitis,[3] and atopic dermatitis.[2] It acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4).[4] It has anti-inflammatory effects.[4][5][6]
It was approved for medical use in the European Union in 2010,[7] in the United States in 2011,[1] and in Canada in 2017.[8] It is available as a generic medication.[9]
Medical uses
Roflumilast is indicated for the treatment of severe chronic obstructive pulmonary disease (COPD),[1] plaque psoriasis,[2][10] seborrheic dermatitis,[3] and atopic dermatitis,[2][11]
It is used in the prevention of exacerbations (lung attacks) in severe chronic obstructive pulmonary disease (COPD).[12][1][7][13][14]
Adverse effects
Common (1–10% incidence) adverse effects include diarrhea, weight loss, nausea, headache, insomnia, decreased appetite, abdominal pain, rhinitis, sinusitis, urinary tract infection, and depression.[1][12][13][14][15]
Society and culture
Legal status
In June 2010, it was approved in the European Union for severe COPD associated with chronic bronchitis.[7][16] In February 2011, it gained FDA approval in the United States for reducing COPD exacerbations.[17][18]
References
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Further reading
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