Ribonucleotide reductase inhibitor
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Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA).
Examples include:
- motexafin gadolinium.[1]
- hydroxyurea[2]
- fludarabine, cladribine, gemcitabine, tezacitabine, and triapine[3]
- gallium maltolate, gallium nitrate[4]
- Tezacitabine, Tezacitabine[5] A chemotherapy candidate nucleotide analogue that failed in clinical trials due to on-target toxicity (febrile neutropenia).[6]
See also
References
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External links
- Ribonucleotide reductase inhibitor entry in the public domain NCI Dictionary of Cancer Terms
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