Ribokinase
Template:Infobox enzyme In enzymology, a ribokinase (EC 2.7.1.15) is an enzyme that catalyzes the chemical reaction
- ATP + <templatestyles src="smallcaps/styles.css"/>d-ribose ⇌ ADP + <templatestyles src="smallcaps/styles.css"/>d-ribose 5-phosphate
Thus, the two substrates of this enzyme are ATP and <templatestyles src="smallcaps/styles.css"/>d-ribose, whereas its two products are ADP and <templatestyles src="smallcaps/styles.css"/>d-ribose 5-phosphate.
The systematic name of this enzyme class is ATP:<templatestyles src="smallcaps/styles.css"/>d-ribose 5-phosphotransferase. Other names in common use include deoxyribokinase, ribokinase (phosphorylating), and <templatestyles src="smallcaps/styles.css"/>d-ribokinase. This enzyme participates in pentose phosphate pathway.
Ribokinase (RK) belongs to the phosphofructokinase B (PfkB) family of sugar kinases.[1] Other members of this family (also known as the RK family) include adenosine kinase (AK), inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase.[1][2][3] The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs and the enzymatic activity of this family of protein generally shows a dependence on the presence of pentavalent ions.[1][2][4] The conserved NXXE motif, which is a distinctive property of the PfkB family of proteins, is involved in pentavalent ion dependency. The structures of RK and several other PfK family of proteins have been determined from a number of organisms.[5] Despite low sequence similarity between AdK and other PfkB family of proteins, these proteins are quite similar at structural levels.[1]
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB2, Template:PDB2, Template:PDB2, Template:PDB2, Template:PDB2, Template:PDB2, and Template:PDB2.
References
<templatestyles src="Reflist/styles.css" />
Script error: No such module "Check for unknown parameters".
Further reading
<templatestyles src="Refbegin/styles.css" />
- Script error: No such module "Citation/CS1".
- Script error: No such module "Citation/CS1".
Script error: No such module "Navbox". Script error: No such module "Navbox". Template:Portal bar