RNASE1
Template:Cs1 config Template:Short description Template:Infobox gene Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]
Function
According to the US National Library of Medicine, "This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA." Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]
References
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Further reading
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External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribonuclease pancreatic
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