RNA-3'-phosphate cyclase
Template:Infobox enzyme In enzymology, a RNA-3′-phosphate cyclase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction
- ATP + RNA 3'-terminal-phosphate AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
Thus, the two substrates of this enzyme are ATP and RNA 3'-terminal-phosphate, whereas its 3 products are AMP, diphosphate, and RNA terminal-2',3'-cyclic-phosphate.
This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming). This enzyme is also called RNA cyclase.
Structural studies
As of 2010, three structures have been solved for this class of enzymes, with PDB accession codes Template:PDB2 and Template:PDB2, (un-adenylated)[1] and Template:PDB2 (adenylated).[2]
References
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Further reading
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