RAB27A

Template:Short description Template:Cs1 config Template:Infobox gene Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

Function

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2 and hemophagocytic lymphohistiocytosis. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

The RAB27A gene is regulated by the Microphthalmia-associated transcription factor.

Interactions

RAB27A has been shown to interact with:

• EXPH5,
• MYO5A,
• RPH3AL
• SYTL1, and
• SYTL2.

See also

• Rab27