Quinazolinone

Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C₄N₂ ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry.

• 2-Quinazolinone
  2-Quinazolinone
• 4-Quinazolinone
  4-Quinazolinone

Synthesis

Common routes to quinazolines involve condensation of amides to anilines with ortho nitrile, carboxylic acids and amides.

Derivatives

Quinazolinone drugs that function as hypnotic/sedatives, methaqualone (Quaalude) for example, usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.

See also

• Idelalisib (Zydelig)
• Cloroqualone
• SL-164 (Dicloqualone)
• Diproqualone
• Etaqualone
• Mebroqualone
• Mecloqualone
• Methylmethaqualone
• Nitromethaqualone