Quinazolinone
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Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C4N2 ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry.[1]
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2-Quinazolinone
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4-Quinazolinone
Synthesis
Common routes to quinazolines involve condensation of amides to anilines with ortho nitrile, carboxylic acids and amides.[2]
Derivatives
Quinazolinone drugs that function as hypnotic/sedatives, methaqualone (Quaalude) for example, usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.
See also
- Idelalisib (Zydelig)
- Cloroqualone
- SL-164 (Dicloqualone)
- Diproqualone
- Etaqualone
- Mebroqualone
- Mecloqualone
- Methylmethaqualone
- Nitromethaqualone
References
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