PyBOP
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PyBOP (benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) is a reagent used to prepare amides from carboxylic acids and amines in the context of peptide synthesis.[1] It can be prepared from 1-hydroxybenzotriazole and a chlorophosphonium reagent under basic conditions.[2] It is a substitute for the BOP reagent that avoids the formation of the carcinogenic waste product HMPA.[3] Thermal hazard analysis by differential scanning calorimetry (DSC) shows PyBOP is potentially explosive.[4]
See also
- BOP reagent
- DEPBT, a related reagent that contains no phosphorus-nitrogen bonds
- HATU
- HBTU
References
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