Protopine
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| Template:Longitem | C20H19NO5 |
| Molar mass | 353.369 g/mol |
| Appearance | white crystals |
| Density | 1.399 g/cm3 |
| Melting point | Template:Chembox CalcTemperatures |
| Solubility in chloroform | 1:15 |
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Protopine is an alkaloid occurring in opium poppy,[2] Corydalis tubers[3] and other plants of the family papaveraceae, like Fumaria officinalis.[4] Protopine is metabolically derived from the benzylisoquinoline alkaloid (S)-Reticuline through a progressive series of five enzymatic transformations: 1) berberine bridge enzyme to (S)-Scoulerine; 2) (S)-cheilanthifoline synthase/CYP719A25 to (S)-Cheilanthifoline; 3) (S)-stylopine synthase/CYP719A20 to (S)-Stylopine; 4) (S)-tetrahydroprotoberberine N-methyltransferase to (S)-cis-N-Methylstylopine; and ultimately, 5) N-methylstylopine hydroxylase to protopine.[5]
It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.[6][7]
See also
References
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- ↑ The Free Dictionary: Protopine
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- ↑ Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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