Prothipendyl
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| Template:Longitem | C16H19N3S |
| Molar mass | 285.40716 |
| Template:Longitem | N05AX07 (WHO) |
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Prothipendyl (brand names Dominal, Timovan, Tolnate), also known as azapromazine or phrenotropin, is an anxiolytic, antiemetic, and antihistamine of the azaphenothiazine group which is marketed in Europe and is used to treat anxiety and agitation in psychotic syndromes.[1][2][3][4] It differs from promazine only by the replacement of one carbon atom with a nitrogen atom in the tricyclic ring system.[1][2] Prothipendyl is said to not possess antipsychotic effects, and in accordance, appears to be a weaker dopamine receptor antagonist than other phenothiazines.[5][4]
Synthesis
See also: Pipazetate.
1-Azaphenothiazine [261-96-1] (1) 3-Dimethylaminopropyl chloride [109-54-6] (2) Sodium hydride suspension
References
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- ↑ von Schlichtegroll, Proc. 1st Int. Congr. Neuro-Pharm. 1958, 408 (1959), C.A. 54, 13400g (1960).
- ↑ Yale, Harry L.; Sowinski, Francis (1958). "10-(Dialkylaminoalkyl)-pyrido[3,2-b][1,4]benzothiazine (1-Azaphenothiazine) and Related Compounds". Journal of the American Chemical Society 80 (7): 1651–1654. doi:10.1021/ja01540a035.
- ↑ Yale, Bernstein, U.S. patent 2943086 (1960 to Olin Mathieson).
- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make linkScript error: No such module "Check for unknown parameters". (1959 to Rhône-Poulenc).
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