Proteinase 3
Template:Short description Template:Infobox gene Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.[1]
Function
PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.[2]
References
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Further reading
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External links
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