Procaterol
Template:Short description Template:Drugbox
Procaterol is a β2 adrenoreceptor agonist used for the treatment of asthma in many countries, but is not approved in the United States. The drug is readily oxidized in the presence of moisture and air, and requires stabilizers for use by inhalation.[1]
It was patented in 1974 and came into medical use in 1980.[2] Procaterol is similar to salbutamol (albuterol), but has a somewhat more prolonged action. It can be taken orally or by inhalation to treat asthma.
Synthesis
8-Hydroxycarbostyril 1 is acylated with 2-bromobutyric acid chloride 2 at the fifth position of the quinoline system, which gives the compound 3. This undergoes action of isopropylamine, forming an aminoketone, the carbonyl group of which is reduced by sodium borohydride, giving procaterol 4.[3][4][5][6]
Names
It is also known as procaterol hydrochloride (USAN).
Procaterol is available under a number of trade names (Onsukil, Masacin, Procadil and others).[7]
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Ghebre-sellassie I, Nesbitt Jr RU, "Procaterol stabilization", published Script error: No such module "auto date formatter"., issued Script error: No such module "auto date formatter"., assigned to Warner Lambert Co LLCScript error: No such module "Check for unknown parameters".
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- ↑ a b <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Nakagawa K, Yoshizaki S, "5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives", issued Script error: No such module "auto date formatter"., assigned to Otsuka Pharmaceutical Co LtdScript error: No such module "Check for unknown parameters".
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