ProSavin
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ProSavin is an experimental drug believed to be of use in the treatment of Parkinson's disease. It is administered to the striatum in the brain, inducing production of dopamine.[1]
It is manufactured by Oxford BioMedica. Results from a Phase I/II clinical trial were published in the Lancet[2] and showed safety, but little efficacy.[3] ProSavin was superseded by AXO-Lenti-PD (OXB-102), an optimized version of the drug.[4]
Mechanism of action
Prosavin uses Oxford BioMedica's Lentivector delivery system to transfer three genes, aromatic amino acid dopa decarboxylase, tyrosine hydroxylase and GTP-cyclohydrolase 1, to the striatum in the brain, reprogramming transduced cells to secrete dopamine.[5][6]
See also
References
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- ↑ Oxford BioMedica. Drug Information Page. Retrieved on March 29, 2007.
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