Polypyrimidine tract-binding protein
Template:Short description Template:Cs1 config Script error: No such module "Infobox".Script error: No such module "Check for unknown parameters". Script error: No such module "Infobox".Script error: No such module "Check for unknown parameters".
Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.[1] Two 2020 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional neurons.[2][3] These studies also show that such a treatment can be applied to the substantia nigra of mice models of Parkinson's disease in order to convert astrocytes to dopaminergic neurons and as a consequence restore motor function in these mice.
See also
References
<templatestyles src="Reflist/styles.css" />
Script error: No such module "Check for unknown parameters".
External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)