Piperidylthiambutene
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Piperidylthiambutene (Piperidinohton) is a synthetic[1] opioid analgesic drug from the thiambutene family, which has around the same potency as morphine.[2][3][4] Piperidylthiambutene is structurally distinct from fentanyl, its analogues, and other synthetic opioids previously reported.[1] If sold or obtained for the purpose of human consumption it could be considered a controlled substance analogue in some countries such as the US, Australia and New Zealand. Piperidylthiambutene has been sold as a designer drug, first appearing in late 2018.[5][6]
Synthesis
The Grignard reaction between 3-Piperidinobutyric acid ethyl ester, CID:10774378 (1) and 2-Bromothiophene [1003-09-4] (2) gives 3. Dehydration in acid completes the synthesis.
References
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- ↑ Adamson Donald Wallace, U.S. patent 2561899 (1951 to Burroughs Wellcome Co).
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