Pimethixene
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Pimethixene is an antihistamine and anticholinergic of the thioxanthene chemical class originally developed to treat hyperactivity,[1] anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator (to dilate the bronchi and bronchioles for more airflow).
In combination with pholcodine, it was sold in France by Laboratoires Salvoxyl in the 1970s as the antitussive Salvodex.[2] Pimethixene alone is still available in Brazil under the trade name Muricalm.
In addition to its other activities, it is a highly potent but non-selective serotonin 5-HT2B receptor antagonist.[3] The selective serotonin 5-HT2B receptor antagonist BF-1 was derived from pimethixene.[3]
See also
References
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