Piberaline
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Piberaline (EGYT-475; Trelibet) is a psychoactive drug and member of the piperazine chemical class which was developed in the 1980s. It has stimulant and antidepressant effects which are thought to be due largely to its active metabolite benzylpiperazine.[1] It was studied to a limited extent in Hungary and Spain, but was not widely accepted and does not seem to be in current use, although a closely related drug befuraline with similar effects has been slightly more successful.
Synthesis
Piberaline can be prepared by reaction of picolinic acid with benzylpiperazine.[2][3][4]
Alternatively, it can be synthesized from 2-chloropyridine, carbon monoxide, and benzylpiperazine.
See also
References
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