Phenpromethamine
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Phenpromethamine (former brand name Vonedrine), also known as N,β-dimethylphenethylamine (MPPA, BMMPEA, β-Me-NMPEA, β,N-MePEA), is a sympathomimetic nasal decongestant of the phenethylamine group.[1][2][3][4] It was previously marketed as a nasal inhaler from 1943 through 1960 but is no longer available.[4][3][5] The medication is a stimulant and is banned by the World Anti-Doping Agency.[6][3] It has been detected in dietary supplements starting in the 2010s.[5][4]
The drug is a monoamine releasing agent (MRA) similarly to β-phenethylamine, amphetamine, and other phenethylamines.[7] It is the N-methyl derivative of β-methylphenethylamine (BMPEA) and the β-methyl derivative of N-methylphenethylamine (NMPEA).[7] Phenpromethamine is known to act as a norepinephrine–dopamine releasing agent (NDRA), with EC50 values of 154Script error: No such module "String".nM for norepinephrine and 574Script error: No such module "String".nM for dopamine in rat brain synaptosomes, whereas serotonin was not reported.[7]
See also
- β,N,N-Trimethylphenethylamine
- Methamphetamine (α-methylphenethylamine)
- Phenacylamine (β-ketophenethylamine)
- Phenylethanolamine (β-hydroxyphenethylamine)
- β-Methylamphetamine
References
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External links
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Template:Monoamine releasing agents
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