Phenomorphan
Template:Short description Template:Drugbox
Phenomorphan[1] is an opioid analgesic. It is not currently used in medicine, but has similar side-effects to other opiates, which include itching, nausea and respiratory depression.
Phenomorphan is a highly potent drug due to the N-phenethyl group, which boosts affinity to the μ-opioid receptor, and so phenomorphan is around 10x more potent than levorphanol, which is itself 6-8x the potency of morphine. Other analogues where the N-(2-phenylethyl) group has been replaced by other aromatic rings[2] are even more potent, with the N-(2-(2-furyl)ethyl) and the N-(2-(2-thienyl)ethyl) analogues being 60x and 45x stronger than levorphanol, respectively.[3]
See also
- 14-Cinnamoyloxycodeinone
- 14-Phenylpropoxymetopon
- 7-PET
- N-Phenethylnormorphine
- N-Phenethylnordesomorphine
- N-Phenethyl-14-ethoxymetopon
- RAM-378
- Ro4-1539
References
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- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Grussner A, Hellerbach J, Schnider O, "Process for making morphinan derivatives and products available thereby", published Script error: No such module "auto date formatter"., issued Script error: No such module "auto date formatter".Script error: No such module "Check for unknown parameters".
- ↑ <templatestyles src="Citation/styles.css"/>Template:Citation/make link, Andre Grussner, Joseph Hellerbach, Otto Schnider, "3-hydroxy-N-(heterocyclic-ethyl)-morphinans", published Script error: No such module "auto date formatter"., issued Script error: No such module "auto date formatter".Script error: No such module "Check for unknown parameters".
- ↑ Script error: No such module "citation/CS1".
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