Periplakin
Template:Cs1 config Template:Short description Template:Infobox gene Periplakin is a protein that in humans is encoded by the PPL gene.[1][2][3]
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.[3]
Interactions
PPL (gene) has been shown to interact with Keratin 8[4] and Envoplakin.[5][6]
See also
References
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Further reading
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