Pecilocin
Template:Cs1 config <templatestyles src="Chembox/styles.css"/>
Template:Chembox image cellTemplate:Chembox AllOtherNamesTemplate:Chembox headerbarTemplate:Chembox IndexlistTemplate:Chembox JmolTemplate:Chembox ChEMBLTemplate:Chembox ECHATemplate:Chembox E numberTemplate:Chembox IUPHAR ligandTemplate:Chembox UNIITemplate:Chembox CompToxTemplate:Chembox headerbarTemplate:Chembox headerbarTemplate:Chembox DrugClassTemplate:Chembox Datapage checkTemplate:Chembox Footer| Template:Longitem | Template:Unbulleted list |
| ChEBI | Template:Unbulleted list |
| ChemSpider | Template:Unbulleted list |
| DrugBank | Template:Unbulleted list |
| EC Number | Template:Unbulleted list |
| KEGG | Template:Unbulleted list |
| Template:Longitem | Template:Unbulleted list |
| RTECS number | Template:Unbulleted list |
| Script error: No such module "collapsible list". | |
| Script error: No such module "collapsible list". | |
| Template:Longitem | C17H25NO3 |
| Molar mass | 291.3853 |
| Appearance | colorless oily substance |
| Solubility in water | 0.181 mg/ml |
| Solubility in organic solvents | high |
| Template:Longitem | D01AA04 (WHO) |
| Template:Longitem | topical (cream or solution) |
Template:Chembox Footer/trackingScript error: No such module "TemplatePar".Template:Short description
Pecilocin (brand name Variotin) is a pyrrolidine anti-fungal.[1] It is produced by Paecilomyces varioti Bainer var. antibioticus and was first isolated by Setsuo Takeuchi in 1959.[2] Later, it was established that other fungi also produce this compound, which include Aspergillus candidus and Aspergillus montenegroi.[3]
Uses
Pecilocin is indicated for topical treatment of fungal infections of skin and its adnexa,[4] i.e.:
- skin mycoses (including tinea versicolor)
- onchomycosis
- scalp infections (e.g. tinea capitis)
Antifungal spectrum
Pecilocin is a fungistatic and has activity against genera Blastomyces, Cryptococcus, Epidermophyton, Microsporum and Trichophyton (with MIC less or equal to 0,25 μg/ml).[5] C. albicans is inherently resistant.
Adverse effects
Common adverse effects associated with pecilocin include: skin irritation (observed in 2-6.5% of patients), as well as contact dermatitis. Some patients might exhibit allergy to pecilocin.[6]
Biosynthesis
A radioactive carbon study of pecilocin biosynthetic pathway conducted by Nobuo Tanaka showed it is synthesised from acetic acid, glutamate and L-methionine.[5]
References
<templatestyles src="Reflist/styles.css" />
Script error: No such module "Check for unknown parameters".