Pagodane
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| Density | 1.629 g/ml |
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Pagodane is an organic compound with formula Template:Chem/link whose carbon skeleton was said to resemble a pagoda, hence the name.[1] It is a polycyclic hydrocarbon whose molecule has the D2h point symmetry group. The compound is a highly crystalline solid that melts at 243 °C, is barely soluble in most organic solvents and moderately soluble in benzene and chloroform. It sublimes at low pressure.[2]
The name pagodane is used more generally for any member of a family of compounds whose molecular skeletons have the same 16-carbon central cage as the basic compound. Each member can be seen as the result of connecting eight atoms of this cage in pairs by four alkane chains. The general member is denoted [m.n.p.q]pagodane where m, n, p and q are the number of carbons of those four chains. The general formula is then Template:Chem/link where s= m+n+p+q. In particular, the basic compound Template:Chem/link has those carbons connected by four methylene bridges (m=n=p=q=1), and its name within that family is therefore [1.1.1.1]pagodane.[2]
Synthesis and structure
The compound was first synthesized by Horst Prinzbach and his associates in 1987, by a 14-step sequence starting from isodrin.[2] In the process they also synthesized [2.2.1.1]pagodane Template:Chem/link and several derivatives.
Prinzbach remarked that "the obvious need for [the short name 'pagodane'] can be readily understood in view of the von Baeyer/IUPAC and Chemical Abstracts nomenclature", undecacyclo[9.9.0.01,5.02,12.02,18.03,7.06,10.08,12.011,15.013,17.016,20]icosane.[2]
In carbon skeleton of pagodane, there can be distinguished many propellane-type fragments.[2]
The overall synthesis can be summarized as follows:[2][3]
The scheme depicted here may be shortened to 14 one-pot operations with 24% overall yield. Yet, this variation requires the use of tetrachlorothiophenedioxide instead of tetrachloro-dimethoxycyclopentadiene in two of the early steps. While fewer steps and higher yield look attractive at first sight, this approach had to be given up due to high cost and restricted availability of the dioxide.[2]
Derivatives
Several derivatives are available, such as the diketone Template:Chem/link (melting point about 322 °C).[2]
Both [1.1.1.1]pagodane and [2.2.1.1]pagodane form dications in [[antimony pentafluoride|Template:Chem/link]]/[[sulfuryl chloride fluoride|Template:Chem/link]]. In these cations the electron deficiency is spread over the central cyclobutane ring.[4][5] These dications were the first examples to show the phenomenon of σ-bishomoaromaticity which was subsequently studied by the Prinzbach group to great length.[6]
Pagodane is an isomer of dodecahedrane and can be chemically converted to it.[7][8]
See also
References
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- ↑ Elegant Solutions: Ten Beautiful Experiments in Chemistry Philip Ball RSC 2005
- ↑ a b c d e f g h Wolf-Dieter Fessner, Gottfried Sedelmeier, Paul R. Spurr, Grety Rihs, H. Prinzbach (1987), "Pagodane": the efficient synthesis of a novel, versatile molecular framework. J. Am. Chem. Soc., volume 109 issue 15, pp. 4626–42 Script error: No such module "CS1 identifiers".
- ↑ H. Prinzbach, F. Wahl, A. Weiler, P. Landenberger, J. Woerth, L.T. Scott, M. Gelmont, D. Olevano, F. Sommer, B. von Issendorff: C20 Carbon Clusters: Fullerene – Boat – Sheet Generation, Mass Selection, PE Characterization. Chem. Eur. J. 2006, 12, 6268-6280 | Script error: No such module "CS1 identifiers".
- ↑ G. K. Surya Prakash (1998), Investigations on intriguing long lived carbodications. Pure & Appl. Chem., volume 70 issue 10, pp. 2001–06. Online version at iupac.org. Retrieved 2010-01-14. Script error: No such module "CS1 identifiers".
- ↑ Stable carbocations. Part 267. Pagodane dication, a unique 2.pi.-aromatic cyclobutanoid system G. K. Prakash, V. V. Krishnamurthy, Rainer. Herges, Robert. Bau, Hanna. Yuan, George A. Olah, Wolf Dieter. Fessner, and Horst. Prinzbach Journal of the American Chemical Society 1986 108 (4), 836-838 Script error: No such module "CS1 identifiers".
- ↑ G.K.S. Prakash, V.V. Krishnamurthy, R. Herges, R. Bau, H. Yuan, G.A Olah, W.-D. Fessner, H. Prinzbach: [1.1.1.1]- and [2.2.1.1]Pagodane Dications: Frozen Two-Electron Woodward-Hoffmann Transition State Models. J. Am. Chem. Soc. 1988, 110, 7764-7772
- ↑ Wolf-Dieter Fessner, Bulusu A. R. C. Murty, Horst Prinzbach (1987), The Pagodane Route to Dodecahedranes – Thermal, Reductive, and Oxidative Transformations of Pagodanes Angewandte Chemie International Edition in English Volume 26, Issue 5, pp. 451–52 Script error: No such module "CS1 identifiers".
- ↑ Wolf-Dieter Fessner, Bulusu A. R. C. Murty, Jürgen Wörth, Dieter Hunkler, Hans Fritz, Horst Prinzbach, Wolfgang D. Roth, Paul von Ragué Schleyer, Alan B. McEwen, Wilhelm F. Maier (1987), Dodecahedranes from [1.1.1.1]Pagodanes. Angewandte Chemie International Edition in English, Volume 26, Issue 5, pp. 452–54 Script error: No such module "CS1 identifiers".
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