PPP2CA
Template:Cs1 config Template:Short description Template:Infobox gene
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.[1]
Function
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.[2]
Interactions
PPP2CA has been shown to interact with:
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- Bcl-2,[3]
- Bestrophin 1,[4]
- CCNG2,[5]
- CTTNBP2NL,[6]
- CTTNBP2,[6]
- Cyclin-dependent kinase 2,[7]
- Cyclin-dependent kinase 6,[7]
- FAM40A,[6]
- IGBP1,[6][8][9][10]
- MOBKL3,[6]
- PPP2R1A,[6][11]
- PPP2R1B,[6][11]
- PPP2R2A,[6][12]
- PPP2R3B,[6][13]
- PPP2R5A,[6][14]
- PPP2R5B,[6][14]
- PPP2R5C,[6][14][15]
- PPP2R5D,[6][14]
- PPP2R5E,[6][14]
- STRN3,[6]
- STRN,[6] and
- TLX1.[16]
See also
References
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Further reading
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