PORCN
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Template:Short description Template:Infobox gene PORCN (porcupine homolog – Drosophila) is a human gene.[1][2] The protein is homologous to other membrane-bound O-acyltransferases.
Function
The protein encoded by this gene is an endoplasmic reticulum transmembrane protein involved in processing of wingless proteins such as WNT7A. It performs O-Palmitoleoylation of these proteins.[2]
Clinical significance
Mutations in this gene are associated with focal dermal hypoplasia.[3]
Mutations in PORCN are associated to Goltz-Gorlin syndrome.[4]
Ligands
Inhibitors
- WNT974 (LGK-974) - 1243244-14-5, researched for anti-cancer effects in Wnt-pathway sensitive tumours.[5] Also investigated for influencing cardiac tissue remodelling following infarction.[6]
IWP (1-4)
RXC004
References
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