POLDIP2
Template:Short description Template:Infobox gene Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2 gene in humans.[1][2]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[2] POLDIP2 / PDIP38 is a moonlighting protein that has been identified in both the nucleus [3] and the mitochondrion [4][5]
Interactions
In the nucleus, POLDIP2 has been shown to interact with PCNA,[1] while in the mitochondrion POLDIP2 has been shown to interact with proteins constituting the mitochondrial DNA nucleoid [6] and the AAA+ protease CLPXP [5][7] where it modulates both the specificity and stability of this proteolytic machine.
References
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Further reading
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