PELO
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Protein pelota homolog is a protein that in humans is encoded by the PELO gene.[1][2]
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.[2] In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs.[3] It is a paralog of the release factor eRF1.
The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes.[4] Human, yeast (Dom34), plant, and worm homologs are reported in 1995,[5] followed by one found in archaea.[6]
References
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Further reading
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