PCP4
Template:Short description Template:Infobox gene Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.[1][2][3] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).[4] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.[4][5]
Function
PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.[4] PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).[4][6][7]
References
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Further reading
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