Oxypertine

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Template:Short description Template:Cs1 config Template:Drugbox

Oxypertine, sold under the brand name Oxypertine among others, is an antipsychotic medication of the pertine group which was previously used in the treatment of schizophrenia but is no longer marketed.[1] It was also evaluated for the treatment of anxiety.[2]

Pharmacology

Pharmacodynamics

The drug shows high affinity for the serotonin 5-HT2 and dopamine D2 receptors (Ki = 8.6Script error: No such module "String".nM and 30Script error: No such module "String".nM, respectively).[3] It antagonizes the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.[3][4] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly contributing to its antipsychotic effectiveness.[5]

Chemistry

Chemically, it is a substituted tryptamine and phenylpiperazine derivative.[6] Its chemical structure is similar to other "pertines" including alpertine, milipertine, and solypertine.[7][8]

History

Oxypertine was first described in the scientific literature by 1962.[9]

Society and culture

Names

Oxypertine is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, and JANTooltip Japanese Accepted Name.[9][10][11][12] It is also known by its former developmental code name WIN-18501.[9][10][11][12] The drug has been sold under brand names including Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil, and Oxypertine.[9][10][11][12]

See also

References

<templatestyles src="Reflist/styles.css" />

  1. ↑ Script error: No such module "citation/CS1".
  2. ↑ Script error: No such module "Citation/CS1".
  3. ↑ a b Script error: No such module "Citation/CS1".
  4. ↑ Script error: No such module "Citation/CS1".
  5. ↑ Script error: No such module "Citation/CS1".
  6. ↑ Script error: No such module "Citation/CS1".
  7. ↑ Script error: No such module "citation/CS1".
  8. ↑ Script error: No such module "citation/CS1".
  9. ↑ a b c d Script error: No such module "citation/CS1".
  10. ↑ a b c Script error: No such module "citation/CS1".
  11. ↑ a b c Script error: No such module "citation/CS1".
  12. ↑ a b c Script error: No such module "citation/CS1".

Script error: No such module "Check for unknown parameters".


Script error: No such module "Navbox".

Template:Dopamine receptor modulators Template:Serotonin receptor modulators Script error: No such module "Navbox".

Retrieved from "http://debianws.lexgopc.com/wiki143/index.php?title=Oxypertine&oldid=6995717"