OxyS RNA
OxyS RNA is a small non-coding RNA which is induced in response to oxidative stress in Escherichia coli. This RNA acts as a global regulator to activate or repress the expression of as many as 40 genes, by an antisense mechanism, including the fhlA-encoded transcriptional activator and the rpoS-encoded sigma(s) subunit of RNA polymerase.[1] OxyS is bound by the Hfq protein, that increases the OxyS RNA interaction with its target messages.[2][3] Binding to Hfq alters the conformation of OxyS.[4] The 109 nucleotide RNA is thought to be composed of three stem-loops.
Target genes
A number of additional targets were predicted and verified using microarray analysis.[5] These are listed below:
- yobF – confirmed by Northern analysis
- yaiZ
- rumA
- wrbA – confirmed by Northern analysis
- ybaY – confirmed by Northern analysis
Furthermore, the mRNA encoded by the nusG gene is a direct target of OxyS.[6]
References
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