Octamer transcription factor
Template:Short description Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]
Human Oct proteins
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- Oct-1 - POU2F1
- Oct-2 - POU2F2
- Oct-3/4 – POU5F1
- Oct-6 – POU3F1
- Oct-7 – POU3F2
- Oct-8 – POU3F3
- Oct-9 – POU3F4
- Oct-11 – POU2F3
References
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)