OSF

OSF may refer to:

Computing

Open Science Framework, a cloud-based management for open access science
Open Semantic Framework, an integrated software stack using semantic technologies for knowledge management
OSF/1, a Unix-like operating system developed by the Open Software Foundation
Opera Show Format, an XHTML-based slideshow format

Ógra Shinn Féin, the youth wing of the Sinn Féin political party
Open Software Foundation, a not-for-profit organization that merged with X/Open and then became The Open Group
Open Society Foundations, a grantmaking body established by George Soros
OpenStack Foundation, a non-profit corporate entity to promote OpenStack software and its community
Operational Support Facility, of the Federal Aviation Administration
Oregon Shakespeare Festival, a repertory theatre in Ashland, Oregon, US
Oxford Scientific Films, a British producer of natural history and documentary programmes
The Old Spaghetti Factory, a restaurant chain
Independent Senate Fraction (Onafhankelijke Senaatsfractie), a political group of the Netherlands
Order of Saint Francis, a 21st-century American Franciscan religious order
Oklahoma Office of State Finance, an agency of the Government of Oklahoma, US
OSF Global Services, a cloud technology company
OSF Healthcare, a non-profit healthcare organization in Illinois and Michigan, US