OR1A1
Template:Short description Template:Infobox gene Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.[1][2]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.[2]
Ligands
OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.[3][4] Examples of known ligands, most of which have citrus or fruity smells:[5][6]
- (S)-(−)-citronellal
- Helional
- Heptanal
- Octanal
- Nonanal (weaker than heptanal/octanal[5])
- Hydroxycitronellal
- Citral
- Citronellol (both enantiomers, weaker than citronellal[5])
- Dihydrojasmone[3]
- Thiols[4]
See also
References
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Further reading
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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