Norfenefrine
Template:Short description Template:Short description <templatestyles src="Infobox drug/styles.css"/> Script error: No such module "Infobox".Template:Template otherScript error: No such module "TemplatePar".{{Infobox drug/maintenance categoriesTemplate:Yesno | drug_name = | INN = | _drugtype =
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| _other_data=3-(2-Amino-1-hydroxyethyl)phenol
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| _datapage = Norfenefrine (data page) | _vaccine_target=_type_not_vaccine | _legal_all=Rx-only | _ATC_prefix_supplemental=C01 | _has_EMA_link = | CAS_number=536-21-0 | PubChem=4538 | ChemSpiderID=4379 | ChEBI=134779 | ChEMBL=358040 | DrugBank=DB13378 | KEGG=D08286 | _hasInChI_or_Key=yes | UNII=D2P3M6SRN5 | _hasJmol02 = |_hasMultipleCASnumbers = |_hasMultiplePubChemCIDs = |_hasMultipleChEBIs =
| _countSecondIDs=Script error: No such module "ParameterCount". | _countIndexlabels=Script error: No such module "ParameterCount". | _trackListSortletter= |QID = |QID2 = |Verifiedfields=changed |Watchedfields= |verifiedrevid=462263073}} Norfenefrine, also known as meta-octopamine or norphenylephrine and sold under the brand name Novadral among others, is a sympathomimetic medication which is used in the treatment of hypotension (low blood pressure).[1][2][3][4] Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring endogenous trace amine and plays a role as a minor neurotransmitter in the brain.[5]
Medical uses
Norfenefrine is used in the treatment of hypotension (low blood pressure).[1] It is said to be similarly effective or less effective than midodrine.[6][7][8]
Pharmacology
Pharmacodynamics
Norfenefrine is described as an α-adrenergic receptor agonist and sympathomimetic agent.[2][4] It is said to act predominantly as an α1-adrenergic receptor agonist.[1]
Chemistry
Norfenefrine, also known as 3,β-dihydroxyphenethylamine, is a substituted phenethylamine derivative.[2][4] It is an analogue of norepinephrine (3,4,β-trihydroxyphenethylamine), of meta-tyramine (3-hydroxyphenethylamine), of phenylephrine ((R)-β,3-dihydroxy-N-methylphenethylamine), of etilefrine (3,β-dihydroxy-N-ethylphenethylamine), and of metaterol (3,β-dihydroxy-N-isopropylphenethylamine), as well as of metaraminol ((1R,2S)-3,β-dihydroxy-α-methylphenethylamine).[2]
Norfenefrine is used medically as the hydrochloride salt.[2][4]
The predicted log P of norfenefrine is -0.28 to -0.95.[9][10][11]
Society and culture
Names
Norfenefrine is the generic name of the drug and its INN.[2][4] Synonyms of norfenefrine include hydroxyphenylethanolamine, nor-phenylephrine, and m-norsynephrine, among others.[2][4] Brand names of norfenefrine include Novadral, A.S. COR, Coritat, Energona, Hypolind, Norfenefrin Ziethen, and Norfenefrin-Ratiopharm, among others.[4]
Availability
Norfenefrine is marketed in Europe, Japan, and Mexico.[4]
References
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