Nitrosourea
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Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.
Examples
Examples include:
- Arabinopyranosyl-N-methyl-N-nitrosourea (Aranose)
- Carmustine (BCNU, BiCNU)
- Chlorozotocin
- Ethylnitrosourea (ENU)
- Fotemustine
- Lomustine (CCNU)
- Nimustine
- N-Nitroso-N-methylurea (NMU)
- Ranimustine (MCNU)
- Semustine
- Streptozocin (Streptozotocin)
Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy.[1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.[2]
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Side effects
Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease.[3]
References
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- ↑ Takimoto CH, Calvo E. "Principles of oncologic pharmacotherapy". in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds) Cancer management: a multidisciplinary approach. 11 ed. 2008.
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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