Niementowski quinazoline synthesis

Template:Reactionbox The Niementowski quinazoline synthesis is the chemical reaction of anthranilic acids with amides to form 4-oxo-3,4-dihydroquinazolines (3H-quinazolin-4-ones).^[1][2][3]

The Niementowski quinazoline synthesis

The Niementowski quinazoline synthesis

Uses

Research has demonstrated that the Niementowski quinazoline synthesis could be employed for the creation of potential EGFR-inhibiting molecules. Hensbergen et al.^[4] have shown a synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring.

File:Synthesis of oxazepino and oxazocino quinazolines.jpg

A nucleophilic aromatic substitution is combined with the Niementowski reaction and a BOP-mediated ring closure to afford several analogues.

References

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