Napoleone Ferrara
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Napoleone Ferrara (born 26 July 1956 in Catania) is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy.[1] At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available angiogenesis inhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers.Script error: No such module "Unsubst". Ferrara's work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders.Script error: No such module "Unsubst".
Education
Ferrara received his medical degree from the University of Catania, Italy, in 1981, and joined Genentech in 1988. He did his postdoctoral research at University of California, San Francisco.[2]
Current research
At UC San Diego Moores Cancer Center, Ferrara, a member of the National Academy of Sciences since 2006, serves as Senior Deputy Director for Basic Science and is a Distinguished Professor of Pathology in the UC San Diego School of Medicine, where he will continue cancer drug research targeting angiogenesis.Script error: No such module "Unsubst". He is presently focusing on investigating mechanisms of tumor angiogenesis alternative to VEGF, in particular the role of factors produced by myeloid cells and fibroblasts in mediating resistance to VEGF inhibitors.Script error: No such module "Unsubst".
Selected honors and awards
For his VEGF discovery, he won a Lasker Award in 2010.[3] In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work.[4] He has received numerous other awards, including the General Motors Cancer Research Award (2006), the ASCO Science of Oncology Award (2007), the Pezcoller Foundation/AACR International Award (2009), the Dr. Paul Janssen Award for Biomedical Research (2011), and The Economist's Innovation Award for bioscience in 2012.Script error: No such module "Unsubst". Grand Prix scientifique de la Fondation Lefoulon-Delalande in 2005.[5]
In September 2014, Ferrara was awarded the António Champalimaud Vision Award, awarded by the Champalimaud Foundation.[6]
2023, Keio Medical Science Prize.[7]
References
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- ↑ Napoleone Ferrara discusses Avastin and the future of anti-angiogenesis therapy, ScienceDirect.
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- ↑ Ferrara Receives Champalimaud Award for Role in Eye Disease Therapy, UC San Diego
- ↑ 第28回（2023年）受賞者
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Template:Breakthrough Prize laureates Template:Authority control
- Pages with script errors
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- 1956 births
- Living people
- Italian molecular biologists
- Genentech people
- University of California, San Diego faculty
- Winners of The Economist innovation awards
- Recipients of the Lasker–DeBakey Clinical Medical Research Award
- University of California, San Francisco alumni
- Scientists from Sicily
- Members of the National Academy of Medicine