NP-40
<templatestyles src="Chembox/styles.css"/>
Template:Chembox image cellTemplate:Chembox AllOtherNamesTemplate:Chembox headerbarTemplate:Chembox IndexlistTemplate:Chembox JmolTemplate:Chembox ChEMBLTemplate:Chembox ECHATemplate:Chembox E numberTemplate:Chembox IUPHAR ligandTemplate:Chembox UNIITemplate:Chembox CompToxTemplate:Chembox headerbarTemplate:Chembox Datapage checkTemplate:Chembox Footer| Template:Longitem | Template:Unbulleted list |
| ChEBI | Template:Unbulleted list |
| ChemSpider | Template:Unbulleted list |
| DrugBank | Template:Unbulleted list |
| EC Number | Template:Unbulleted list |
| KEGG | Template:Unbulleted list |
| Template:Longitem | Template:Unbulleted list |
| RTECS number | Template:Unbulleted list |
| UN number | 3082 |
| Script error: No such module "collapsible list". | |
| Script error: No such module "collapsible list". | |
| Template:Longitem | H(C2H4O)nO(C6H4)C9H19 |
| Molar mass | Variable |
Template:Chembox Footer/trackingScript error: No such module "TemplatePar".Template:Short description
NP-40 (also known as Tergitol-type NP-40 and nonyl phenoxypolyethoxylethanol[1]) is a commercially available detergent with CAS Registry Number 9016-45-9. NP-40 is an ethoxylated nonylphenol for non-ionic surfactants and can act as emulsifier and demulsifier agent.
NP-40 is often used to break open all membranes within a cell, including the nuclear membrane Script error: No such module "Unsubst".. To break only the cytoplasmic membrane, other detergents such as digitonin can be used.
NP-40 has applications in paper and textile processing, in paints and coatings, and in agrochemical manufacturing.
Care should be taken to avoid confusing NP-40 with Nonidet P-40 (octyl phenoxypolyethoxylethanol) which is currently out of production. Nonidet P-40 ("Non-Ionic Detergent") was originally manufactured and trademarked by the Shell Chemical Company,[2] but was phased out of production in the early 2000s. Confusingly, biochemical protocols published between the 1960s[3] and 2000s refer to Shell's Nonidet P-40 as NP-40. Shell's original Nonidet P-40 had a hydrophilic-lipophilic balance (HLB) value of 13.5,[4] as opposed to 12.9 for the currently available IGEPAL CA-630,[5] indicating that the currently available compound is more potent than the compound used in older publications. Indeed, according to a 2017 report,[6] an additional dilution factor of 10 was required for the currently available NP-40 ("Nonidet P-40 substitutes") to match the activity of the previously available, and now discontinued, Shell's Nonidet P-40.
See also
- Nonoxynol-9
- Surfactant
- Lipid bilayer
- Detergent
- Triton X-100 (differs only in the # of carbons in the aliphatic portion)
References
<templatestyles src="Reflist/styles.css" />
- ↑ NP-40 Surfact-Amps Detergent Solution
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ TERGITOL NP-9 Surfactant
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".