NDEL1
Template:Short description Template:Infobox gene Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.[1][2][3]
It plays a significant role in intracellular transport and the process of cellular division via regulation of the dynein motor protein and its cofactor protein, Lis1.[4] Ndel1 is a highly conserved protein and its human gene, NDEL1 is expressed in a wide variety of brain tissues which contributes to neuronal function and development.[5][6][7] Nde1 and Ndel1 were in the past referred to as NudE and NudEL respectively.[8][9] The Nde1 protein is involved in nuclear migration throughout the process of neurogenesis.[10] Studies have revealed that Ndel1 is structurally similar to Nde1 which both play a role in microtubule-based transport.[4] Ndel1 and Nde1 are also thought to be associated with neurodevelopmental and psychiatric disorders.[10][11] Secondary structure of Ndel1 is composed of various distinct domains: a C-terminal region, and a 200 amino acid N-terminal coiled-coil domain. The coiled-coil domain of Ndel1 serves as a self-associating stable parallel homodimer.[12] Such structural components help with interactions between an array of binding partners, including the motor protein dynein and its cofactor protein, Lis1. Ndel1 forms a heterotetramer complex with Lis1 via the N-terminal coiled-coil domain.[12] The Ndel1 N-terminal coiled-coil domain mediates binding to dynein, whereas the C-terminal domain interacts with Lis1, regulating the activity of the dynein complex.[9]
This gene product is a thiol-activated oligopeptidase and is also known as Endooligopeptidase A in that context. It is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
Other Interactions
NDEL1 has been shown to interact with Cyclin-dependent kinase 5,[1] YWHAE,[13] PAFAH1B1[1][13] and DISC1.[14][15]
References
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Further reading
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